郭明良 Kuo, Min-Liang
教授


電話:886-2-2312-3456 #88607
傳真:886-2-2341-0217
電子信箱:kuominliang@ntu.edu.tw
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個人檔案

2012/08 -迄今 國立臺灣大學生命科學院 院長
2012/08 -迄今 國立臺灣大學生命科學院生科學研究所 教授
2012/08 -迄今 國立臺灣大學漁業生物試驗所 所長
2012/08 -迄今 國立臺灣大學醫學院 毒理學研究所 合聘教授
2009/08 -2012/07 行政院國家科學委員會 生物科學發展處 處長
2007/08 -2009/07 國立臺灣大學醫學院 副院長兼研發室主任
1999/08 -2012/07 國立臺灣大學醫學院 毒理學研究所 教授
2006/07 -2007/07 美國德州大學安德森癌症中心 訪問學者
1999/08 -2005/07 國立臺灣大學醫學院 毒理學研究所 所長
1993/02 -1999/07 國立臺灣大學醫學院 毒理學研究所 副教授
1991/05 -1993/01 國立臺灣大學醫學院 毒理學研究所 講師
1989/02 -1989/07 中央研究院生醫所 博士後研究員

研究成果

獲得獎項
91-93年度傑出研究獎-
國家科學委員會

89年度傑出研究獎-
中華民國癌症醫學會

89-90年度傑出研究獎-
國家科學委員會

第九十三年度杜聰明博士紀念演講獎-
台灣醫學會

第十四屆王民寧獎-
財團法人王民寧先生紀念基金會

第三屆徐有庠科技論文獎-
財團法人徐有庠先生紀念基金會

97年第五十二屆教育學術獎-生物及醫學科
教育部

Refereed Publications:(2002-present)
1. Huang SP, Wu MS, Wang HP, Yang CS, Kuo ML, Lin JT. Correlation between serum levels of interleukin-6 and vascular endothelial growth factor in gastric carcinoma. J Gastroenterol Hepatol. 17(11):1165-9, 2002.

2. Jee SH, Chiu HC, Tsai TF, Tsai WL, Liao YH, Chu CY, Kuo ML*. The phosphotidyl inositol 3-kinase/Akt signal pathway is involved in interleukin-6-mediated Mcl-1 upregulation and anti-apoptosis activity in basal cell carcinoma cells. J Invest Dermat. 119(5):1121-7, 2002.

3. Wang FI, Kuo ML, Shun CT, Ma YC, Wang JD, Ueng TH. Chronic toxicity of a mixture of chlorinated alkanes and alkenes in ICR mice. J Toxicol Environ Health A. 65(3-4):279-91, 2002.

4. Lin MT, Yeh SL, Kuo ML, Liaw KY, Lee PH, Chang KJ, Chen Wj. Effects of medium-chain triglyceride in parenteral nutrition on rats undergoing gastrectomy. Clin Nutr. 21(1):39-43, 2002.

5. Antlsperger DS, Dirsch VM, Ferreira D, Su JL, Kuo ML, Vollmar AM. Ajoene-induced cell death in human promyeloleukemic cells does not require JNK but is amplified by the inhibition of ERK. Oncogene 22(4):582-9, 2003.

6. Tsai PW, Shiah SG, Lin MT, Wu CW, Kuo ML*. Up-regulation of vascular endothelial growth factor C in breast cancer cells by heregulin-beta1. A critical role of p38/NF-kB signaling pathway. J Biol Chem. 278(8):5750-9, 2003.

7. Chen JJ, Yao PL, Yuan A, Hong TM, Shun CT, Kuo ML, Lee YC, Yang PC. Up-regulation of tumor interleukin-8 expression by infliltrating macrophages: its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer. Clin Cancer Res. 9(2):729-37, 2003.

8. Lin MT, Yen ML, Lin CY, Kuo ML*. Inhibition of vascular endothelial growth factor-induced angiogenesis by resveratrol through interruption of Src-dependent vascular endothelial cadherin tyrosine phosphorylation. Mol Pharmacol. 64(5):1029-36, 2003.

9. Yang CH, Chen YC, Kuo ML*. Novobiocin sensitizes BCRP/MXR/ABCP overexpressing topotecan-resistant human breast carcinoma cells to topotecan and mitoxantrone. Anticancer Res. (3B):2519-23, 2003.

10. Shih WL, Kuo ML, CHuang SE, Cheng AL, Doong SL. Hepatitis B virus X protein activates a survival signaling by linking SRC to phosphatidylinositol 3-kinase. J Biol Chem. 278(34):31807-13, 2003.

11. Wei LH, Kuo ML, Chen CA, Chou CH, Lai KB, Lee CN, Hsieh CY. Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway. Oncogene 22(10):1517-27, 2003.

12. Yang CH, Chen YC, Kuo ML*. Novobiocin sensitizes BCRP/MXR/ABCP overexpressing topotecan-resistant human breast carcinoma cells to topotecan and mitoxantrone. Anticancer Res. 23(3B):2519-23, 2003.

13. Tzeng HP, Ho FM, Chao KF, Kuo ML, Lin-Shiau SY, Liu. SH. beta-Lapachone reduces endotoxin-induced macrophage activation and lung edema and mortality. Am J Respir Crit Care Med. 168(1)85-91, 2003.

14. Su JL, Shih JY, Yen Ml, Jeng YM, Chang CC, Hsieh CY, Wei LH, Yang PC, Kuo ML*. Cyclooxygenase-2 induces EP1-and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma. Cancer Res. 64(2):554-64, 2004.

15. Hsieh CY, Chen CA, Chou CH, Lai KP, Jeng YM, Kuo ML, Wei LH. Overexpression of Her-2/NEU in epithelial ovarian carcinoma induces vascular endothelial growth factor C by activating Nf-kappa B: implications for malignant ascites formation and tumor lymphangiogenesis. J Biomed Sci. 11(2):249-59, 2004.

16. Chang CC, Shih JY, Jeng YM, Su JL, Lin BZ, Chen ST, Chau YP, Yang PC, Kuo ML*. Connective tissue growth factor and its role in lung adenocarcinoma invasion and metastasis. J Natl Cancer Inst. 96(5):364-75, 2004.

17. Lin MT, Chang CC, Chen ST, Chang HL, Su JL, Chau YP, Kuo ML*. Cyr61 expression confers resistance to apoptosis in breast cancer MCF-7 cells by a mechanism of NF-kappaB-dependent XIAP up-regulation. J Biol Chem. 279(23):24015-23, 2004.

18. Pu YS, Hour TC, Chuang SE, Cheng AL, Lai MK, Kuo ML*. Intleukin-6 is responsible for drug resistance and anti-apoptotic effects in prostatic cancer cells. Prostate. 60(2):120-9, 2004.

19. Sheu ML, Ho FM, Chao KF, Kuo ML, Liu SH. Activation of phosphoinositide 3-kinase in response to high glucose leads to regulation of reactive oxygen species-related nuclear factor-kappaB activation and cyclooxygenase-2 expression in mesangial cell. Mol Pharmacol. 66(1):187-96, 2004.

20. Jee SH, Chu CY, Chiu HC, Huang YL, Tsai WL, Liao YH, Kuo ML*. Interleukin-6 induced basic fibroblast growth factor-dependent angiogenesis in basal cell carcinoma cell line via JAK/STAT3 and PI3-kinase/Akt pathways. J Invest Dermatol 123(6):1169-75, 2004.

21. Huang SP, Wu MS, Shun CT, Wang HP, Lin MT, Kuo ML, Lin JT. Interleukin-6 increases vascular endothelial growth factor and angiogenesis in gastric carcinoma. J Biomed Sci. 11(4):517-27, 2004.

22. Shih CK, Chiang W, Kuo ML*. Effects of adlay on azoxymethane-induced colon carcinogenesis in rats. Food Chem Toxicol. 42(8):1339-47, 2004.

23. Huang SP, Wu MS, Shun CT, Wang HP, Hsieh CY, Kuo ML, Lin JT. Cyclooxygenase-2 increases hypoxia-inducible factor-1 and vascular endothelial growth factor to promote angiogenesis in gastric carcinoma. J Biomed Sci. 12(1):229-41, 2005.

24. Lin BR, Chang CC, Che TF, Chen ST, Chen JC Robert, Yang CY, Jeng YM, Liang JT, Lee PH, Chang KJ, Chau YP, Kuo ML*. Connective Tissue Growth Factor Inhibits Metastasis and Acts as an Independent Prognostic Marker in Colorectal Cancer. Gastroenterology 128 (1): 9- 23, 2005.

25. Su JL, Lin MT, Hong CC, Chang CC, Shiah SG, Wu CW, Chen ST, Chau YP, Kuo ML*. Resveratrol induces FasL-related apoptosis through Cdc42 activation of ASK1/JNK-dependent signaling pathway in human leukemia HL-60 cells. Carcinogenesis 26(1):1-10, 2005.

26. Chou CH, Wei LH, Kuo ML, Huang YJ, Lai KP, Chen CA, Hsieh CY. Up-regulation of interleukin-6 in human ovarian cancer cell via a Gi/PI3K-Akt/NF-kappaB pathway by lysophosphatidic acid, an ovarian cancer-activating factor. Carcinogenesis 26(1):45-52, 2005.

27. Wei LH, Lai KP, Chen CA, Cheng CH, Huang YJ, Chou CH, Kuo ML, Hsieh CY. Arsenic trioxide prevents radiation-enhanced tumor invasiveness and inhibits matrix metalloproteinase-9 through downregulation of nuclear factor kappaB. Oncogene 24(3):390-8, 2005.

28. Hsu WM, Hsieh FJ, Jeng YM, Kuo ML, Chen CN, Lai DM, Hsieh LJ, Wang BT, Tsao PN, Lee H, Lin MT, Lai HS, Chen WJ. Calreticulin expression in neuroblastoma--a novel independent prognostic factor. Ann Oncol. 16(2):314-21, 2005.

29. Hsu WM, Hsieh FJ, Jeng YM, Kuo ML, Tsao PN, Lee H, Lin MT, Lai HS, Chen CN, Lai DM, Chen WJ. GRP78 expression correlates with histologic differentiation and favorable prognosis in neuroblastic tumors. Int J Cancer 113(6):920-7, 2005.

30. Su JL, Lai KP, Chen CA, Yang CY, Chen PS, Chang CC, Chou CH, Hu CL, Kuo ML, Hsieh CY, Wei LH. A novel peptide specifically binding to interleukin-6 receptor (gp80) inhibits angiogenesis and tumor growth. Cancer Res. 65(11):4827-35, 2005.

31. Lin MT, Zuon CY, Chang CC, Chen ST, Chen CP, Lin BR, Wang MY, Jeng YM, Chang KJ, Lee PH, Chen WJ, Kuo ML*. Cyr61 induces gastric cancer cell motility/invasion via activation of the integrin/nuclear factor-kappaB/cyclooxygenase-2 signaling pathway. Clin Cancer Res. 11(16):5809-20, 2005.

32. Yen ML, Su JL, Chien CL, Tseng KW, Yang CY, Chen WF, Chang CC, Kuo ML*. Diosgenin induces HIF-1 activation and angiogenesis through estrogen receptor-related PI3K/Akt and p38 MAPK pathways in osteoblasts. Mol Pharmacol. 68(4):1061-73, 2005.

33.Ueng TH, Hung CC, Kuo ML, Chan PK, Hu SH, Yang PC, Chang LW. Induction of Fibroblast Growth Factor-9 and Interleukin-1{alpha} Gene Expression by Motorcycle Exhaust Particulate Extracts and Benzo(a)pyrene in Human Lung Adenocarcinoma Cells. Toxicol Sci. 2005.

34. Chen CN, Lin JJ, Chen JJ, Lee PH, Yang CY, Kuo ML, Chang KJ, Hsieh FJ. Gene expression profile predicts patient survival of gastric cancer after surgical resection. J Clin Oncol. 23(29):7286-95, 2005.

35. Lin MT, Kung SP, Yeh SL, Liaw KY, Wang MY, Kuo ML, Lee PH, Chen WJ. Glutamine-supplemented total parenteral nutrition attenuates plasma interleukin-6 in surgical patients with lower disease severity. World J Gastroenterol. 21;11(39):6197-201, 2005.

36. Lu YS, Lien HC, Yeh PY, Yeh KH, Kuo ML, Kuo SH, Cheng AL. Effects of glucocorticoids on the growth and chemosensitivity of carcinoma cells are heterogeneous and require high concentration of functional glucocorticoid receptors. J Endocrinol. 188(2):311-9, 2005.

37. Lu YS, Yeh PY, Chuang SE, Gao M, Kuo ML, Cheng AL. Glucocorticoids enhance cytotoxicity of cisplatin via suppression of NF-{kappa}B activation in the glucocorticoid receptor-rich human cervical carcinoma cell line SiHa. J Endocrinol. 188(2):311-9, 2006.

38. Hsu WM, Jen YM, Lee H, Kuo ML, Tsao PN, Chen CN, Lai DM, Lin MT, Lai HS, Chen WJ, Hsieh FJ. The influence of biologic factors on the surgical decision in advanced neuroblastoma. Ann Surg Oncol. 13(2):238-44, 2006.

39. Su JL, Yang CY, Shih JY, Wei LH, Hsieh CY, Jeng YM, Wang MY, Yang PC, Kuo ML*. Knockdown of contactin-1 expression suppresses invasion and metastasis of lung adenocarcinoma. Cancer Res. 66(5):2553-61, 2006.

40. Su JL, Yang PC, Shih JY, Yang CY, Wei LH, Hsieh CY, Chou CH, Jeng YM, Wang MY, Chang KJ, Hung MC, Kuo ML*. The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells. Cancer Cell 9(3):209-23, 2006.

41. Tjiu JW, Liao YH, Lin SJ, Huang YL, Tsai WL, Chu CY, Kuo ML, Jee SH. Cyclooxygenase-2 Overexpression in Human Basal Cell Carcinoma Cell Line Increases Antiapoptosis, Angiogenesis, and Tumorigenesis. J Invest Dermatol., 2006.

42. Chang CC, Lin MT, Lin BR, Jeng YM, Chen ST, Chu CY, Chen RJ, Chang KJ, Yang PC, Kuo ML*. Effect of connective tissue growth factor on hypoxia-inducible factor 1alpha degradation and tumor angiogenesis. J Natl Cancer Inst. 98(14):984-95, 2006.

43. Lu YS, Lien HC, Yeh PY, Kuo SH, Chang WC, Kuo ML, Cheng AL. Glucocorticoid receptor expression in advanced non-small cell lung cancer: clinicopathological correlation and in vitro effect of glucocorticoid on cell growth and chemosensitivity. Lung Cancer 53(3):303-10, 2006.

44. ChouCheng JC, Chou CH, Kuo ML, Hsieh CY. Radiation-enhanced hepatocellular carcinoma cell invasion with MMP-9 expression through PI3K/Akt/NF-kappaB signal transduction pathway. Oncogene 25(53):7009-18, 2006.

45. Su JL, Yen CJ, Chen PS, Chuang SE, Hong CC, Kuo IH, Chen HY, Hung MC, Kuo ML*.The role of the VEGF-C/VEGFR-3 axis in cancer progression. Br J Cancer 96(4):541-5, 2007

46. Chu CY, Cha ST, Chang CC, Hsiao CH, Tan CT, Lu YC, Jee SH, Kuo ML*.Involvement of matrix metalloproteinase-13 in stromal-cell-derived factor 1 alpha-directed invasion of human basal cell carcinoma cells. Oncogene 26(17):2491-501, 2007.

47. Chen PS, Wang MY, Wu SN, Su JL, Hong CC, Chuang SE, Chen MW, Hua KT, Wu YL, Cha ST, Babu MS, Chen CN, Lee PH, Chang KJ, Kuo ML*. CTGF enhances the motility of breast cancer cells via an integrin-alphavbeta3-ERK1/2-dependent S100A4-upregulated pathway. J Cell Sci. 120(Pt 12):2053-65, 2007.

48. Lin MT, Lin BR, Chang CC, Chu CY, Su HJ, Chen ST, Jeng YM, Kuo ML*. IL-6induces AGS gastric cancer cell invasion via activation of the c-Src/RhoA/ROCK signaling pathway. Int J Cancer 120(12):2600-8, 2007.

49. Su JL, Yang CY, Zhao M, Kuo ML, Yen ML. Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. J Biol Chem. 282(27):19385-98, 2007.

50. Lin BR, Chang CC, Chen LR, Wu MH, Wang MY, Kuo IH, Chu CY, Chang KJ, Lee PH, Chen WJ, Kuo ML, Lin MT. Cysteine-rich 61 (CCN1) enhances chemotactic migration, transendothelial cell migration, and intravasation by concomitantly up-regulating chemokine receptor 1 and 2. Mol Cancer Res. 5(11):1111-23, 2007.

51. Lin MT, Chang CC, Lin BR, Yang HY, Chu CY, Wu MH, Kuo ML*. Elevated expression of Cyr61 enhances peritoneal dissemination of gastric cancer cells through integrin alpha2beta1. J Biol Chem. 282(47):34594-604, 2007.

52. Lin MT, Kuo IH, Chen CC, Chu CY, Chen HY, Lin BR, Sureshbabu M, Shih HJ, Kuo ML. Involvement of HIF-1alpha -dependent PAI-1 up-regulation in Cyr61/CCN1 induced gastric cancer cell invasion. J Biol Chem. 2008 (in press)

53. Ho PY, Hsu SP, Liang YC, Kuo ML, Ho YS, Lee WS. Inhibition of the ERK phosphorylation plays a role in terbinafine-induced p21 up-regulation and DNA synthesis inhibition in human vascular endothelial cells. Toxicol Appl Pharmacol. 2008 (in press)
54. Chu CY, Cha ST, Lin WC, Lu PH, Tan CT, Chang CC, Lin BR, Jee SH, Kuo ML *. Stromal-cell-derived factor-1{alpha} (SDF-1{alpha}/CXCL12)-enhanced angiogenesis of human basal cell carcinoma cells involves ERK1/2-NF-{kappa} B/interleukin-6 pathway. Carcinogenesis. 30(2):205-13, 2009.
55. Tjiu JW, Chen JS, Shun CT, Lin SJ, Liao YH, Chu CY, Tsai TF, Chiu HC, Dai YS, Inoue H, Yang PC, Kuo ML , Jee SH. Tumor-Associated Macrophage-Induced Invasion and Angiogenesis of Human Basal Cell Carcinoma Cells by Cyclooxygenase-2 Induction. J Invest Dermatol.129(4):1016-25, 2009.
56. Chen CN, Chang CC, Su TE, Hsu WM, Jeng YM, Ho MC, Hsieh FJ, Lee PH, Kuo ML, Lee H, Chang KJ. Identification of calreticulin as a prognosis marker and angiogenic regulator in human gastric cancer. Ann Surg Oncol. 16(2):524-33. 2009.
57. Wang MY, Chen PS, Prakash E, Hsu HC, Huang HY, Lin MT, Chang KJ, Kuo ML. Connective tissue growth factor confers drug resistance in breast cancer through concomitant up-regulation of Bcl-xL and cIAP1. Cancer Res 69(8):3482-91. 2009.
58. Yu CC, Hsu MJ, Kuo ML, Chen RF, Chen MC, Bai KJ, Yu MC, Chen BC, Lin CH. Thrombin-induced connective tissue growth factor expression in human lung fibroblasts requires the ASK1/JNK/AP-1 pathway. J Immunol. 15;182(12):7916-27. 2009 Jun.
59. Chien MH, Ku CC, Johansson G, Chen MW, Hsiao M, Su JL, Inoue H, Hua KT, Wei LH, Kuo ML. Vascular endothelial growth factor-c (VEGF-C) promotes angiogenesis by induction of COX-2 in leukemic cells via the VEGF-R3/JNK/AP-1 pathway. Carcinogenesis. 2009 Oct 13. [Epub ahead of print]
60. Hsu KW, Hsieh RH, Wu CW, Chi CW, Lee YH, Kuo ML, Wu KJ, Yeh TS. MBP-1 Suppresses Growth and Metastasis of Gastric Cancer Cells through COX-2. Mol Biol Cell. 2009 Oct 21. [Epub ahead of print]
61. H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM. Cancer Res. 2010 Oct 15;70(20):7830-40.
62. MicroRNA-519c suppresses hypoxia-inducible factor-1alpha expression and tumor angiogenesis. Cancer Res. 2010 Apr 1;70(7):2675-85.
63. N-α-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity. Cancer Cell. 2011 Feb 15;19(2):218-31.
64. Efficient Derivation & Concise Gene Expression Profiling of Human Embryonic Stem Cell-Derived Mesenchymal Progenitors (EMPs). Cell Transplant. 2011 Mar 7. doi: 10.3727/096368910X564067.
65. Connective tissue growth factor acts as a therapeutic agent and predictor for peritoneal carcinomatosis of colorectal cancer. Clin Cancer Res. 2011 May 15;17(10):3077-88.
66. miR-107 promotes tumor progression by targeting the let-7 microRNA in mice and humans. J Clin Invest. 2011 Sep 1;121(9):3442-55.
67. CCN2 inhibits lung cancer metastasis through promoting DAPK-dependent anoikis and inducing EGFR degradation. Cell Death and Differentiation. Epub ahead of print. 2012. doi:10.1038/cdd.2012.136.