Min-Liang Kuo
Professor


LABIBS R310

TEL886-2-3366-5960(College of Life Science)

      886-2-2312-3456 #88607(Institute of Toxicology College of Medicine )

FAX2364-0353(College of Life Science)

      2363-5038(Institute of Biochemical Sciences)

 

 

e-mail: kuominliang@ntu.edu.tw

 

 

 

 

Personal Files

Education

1985 -1989 Ph.D., Institute of Biochemistry, National Taiwan University
1984 -1985 M.S., Institute of Biochemistry, National Taiwan University
1980 -1984 B.A., Institute of Food Science, Catholic Fu-Jen University

Professional experience

2012~ Present Dean, College of Life Science, National Taiwan University
2012~ Present Director, Institute of fishery Biology, National Taiwan University College of Life Science
2012~ Present Professor, Institute of Biochemical Science, National Taiwan University College of Life Science
2012~ Present Co-hiring Professor, Institute of Toxicology College of Medicine National Taiwan University
2009~ 2012 Director General, Department of Life Sciences, National Science Council Republic of China
2007~ 2009 Distinguished Professor Associated Dean, Director of R&D, Institute of Toxicology College of Medicine National Taiwan University
2006~ 2007 M.D., Department of Molecular Oncology MD Anderson Cancer Center
2005~ 2006 Professor, Institute of Toxicology College of Medicine National Taiwan University
1999~ 2005 Professor and Director, Institute of Toxicology College of Medicine National Taiwan University
1993~ 1999 Associate Professor, Institute of Toxicology College of Medicine National Taiwan University
1991~ 1993 Lecturer, Institute of Toxicology College of Medicine National Taiwan University
1989~ 1990 Post Doctoral Fellow, Institute of Biomedicine Science, Academic Sinica.

The Research

Publication
1. Chang CC, Yang MH, Lin BR, Chen ST, Pan SH, Hsiao M, Lai TC, Lin SK, Jeng YM, Chu CY, Chen RH, Yang PC, Chin Y Eugene and Kuo ML*. CCN2 inhibits lung cancer metastasis through promoting DAPK-dependent anoikis and inducing EGFR degradation. Cell Death and Differentiation. Epub ahead of print. 2012. doi:10.1038/cdd.2012.136.
2. Chen PS, Su JL, Cha ST, Tarn WY, Wang MY, Hsu HC, Lin MT, Chu CY, Hua KT, Chen CN, Kuo TC, Chang KJ, Hsiao M, Chang YW, Chen JS, Yang PC, Kuo ML*. miR-107 promotes tumor progression by targeting the let-7 microRNA in mice and humans. J Clin Invest. 2011 Sep 1;121(9):3442-55.
3. Lin BR, Chang CC, Chen RJ, Jeng YM, Liang JT, Lee PH, Chang KJ, Kuo ML*. Connective tissue growth factor acts as a therapeutic agent and predictor for peritoneal carcinomatosis of colorectal cancer. Clin Cancer Res. 2011 May 15;17(10):3077-88.
4. Yen ML, Hou CH, Peng KY, Tseng PC, Jiang SS, Shun CT, Chen YC, Kuo ML*. Efficient Derivation & Concise Gene Expression Profiling of Human Embryonic Stem Cell-Derived Mesenchymal Progenitors (EMPs). Cell Transplant. 2011 Mar 7. doi: 10.3727/096368910X564067.
5. Hua KT, Tan CT, Johansson G, Lee JM, Yang PW, Lu HY, Chen CK, Su JL, Chen PB, Wu YL, Chi CC, Kao HJ, Shih HJ, Chen MW, Chien MH, Chen PS, Lee WJ, Cheng TY, Rosenberger G, Chai CY, Yang CJ, Huang MS, Lai TC, Chou TY, Hsiao M, Kuo ML*. N-α-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity. Cancer Cell. 2011 Feb 15;19(2):218-31.
6. Chen MW, Hua KT, Kao HJ, Chi CC, Wei LH, Johansson G, Shiah SG, Chen PS, Jeng YM, Cheng TY, Lai TC, Chang JS, Jan YH, Chien MH, Yang CJ, Huang MS, Hsiao M, Kuo ML*.H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM. Cancer Res. 2010 Oct 15;70(20):7830-40.
7. Cha ST, Chen PS, Johansson G, Chu CY, Wang MY, Jeng YM, Yu SL, Chen JS, Chang KJ, Jee SH, Tan CT, Lin MT, Kuo ML*. MicroRNA-519c suppresses hypoxia-inducible factor-1alpha expression and tumor angiogenesis. Cancer Res. 2010 Apr 1;70(7):2675-85.
8. Chien MH, Ku CC, Johansson G, Chen MW, Hsiao M, Su JL, Inoue H, Hua KT, Wei LH, Kuo ML*. Vascular endothelial growth factor-C (VEGF-C) promotes angiogenesis by induction of COX-2 in leukemic cells via the VEGF-R3/JNK/AP-1 pathway. Carcinogenesis. 2009 Dec;30(12):2005-13.
9. Wang MY, Chen PS, Prakash E, Hsu HC, Huang HY, Lin MT, Chang KJ, Kuo ML*. Connective tissue growth factor confers drug resistance in breast cancer through concomitant up-regulation of Bcl-xL and cIAP1. Cancer Res. 2009 Apr 15;69(8):3482-91.
10. Chu CY, Cha ST, Lin WC, Lu PH, Tan CT, Chang CC, Lin BR, Jee SH, Kuo ML*. Stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12)-enhanced angiogenesis of human basal cell carcinoma cells involves ERK1/2-NF-kappaB/interleukin-6 pathway. Carcinogenesis. 2009 Feb;30(2):205-13.
11. Chu CY, Chang CC, Prakash E, Kuo ML*. Connective tissue growth factor (CTGF) and cancer progression. J Biomed Sci. 2008 Nov;15(6):675-85.
12. Su JL, Chen PS, Chien MH, Chen PB, Chen YH, Lai CC, Hung MC, Kuo ML*. Further evidence for expression and function of the VEGF-C/VEGFR-3 axis in cancer cells. Cancer Cell. 2008 Jun;13(6):557-60.
13. Tan CT, Chu CY, Lu YC, Chang CC, Lin BR, Wu HH, Liu HL, Cha ST, Prakash E, Ko JY, Kuo ML*. CXCL12/CXCR4 promotes laryngeal and hypopharyngeal squamous cell carcinoma metastasis through MMP-13-dependent invasion via the ERK1/2/AP-1 pathway. Carcinogenesis. 2008 Aug;29(8):1519-27.
14. Lin MT, Kuo IH, Chang CC, Chu CY, Chen HY, Lin BR, Sureshbabu M, Shih HJ, Kuo ML*. Involvement of hypoxia-inducing factor-1alpha-dependent plasminogen activator inhibitor-1 up-regulation in Cyr61/CCN1-induced gastric cancer cell invasion. J Biol Chem. 2008 Jun 6;283(23):15807-15.
15. Lin MT, Chang CC, Lin BR, Yang HY, Chu CY, Wu MH, Kuo ML*. Elevated expression of Cyr61 enhances peritoneal dissemination of gastric cancer cells through integrin alpha2beta1. J Biol Chem. 2007 Nov 23;282(47):34594-604.
16. Chen PS, Wang MY, Wu SN, Su JL, Hong CC, Chuang SE, Chen MW, Hua KT, Wu YL, Cha ST, Babu MS, Chen CN, Lee PH, Chang KJ, Kuo ML*. CTGF enhances the motility of breast cancer cells via an integrin-alphavbeta3-ERK1/2- dependent S100A4-upregulated pathway. J Cell Sci. 2007 Jun 15;120(Pt 12):2053-65.
17. Lin MT, Lin BR, Chang CC, Chu CY, Su HJ, Chen ST, Jeng YM, Kuo ML*. IL-6 induces AGS gastric cancer cell invasion via activation of the c-Src/RhoA/ROCK signaling pathway. Int J Cancer. 2007 Jun 15;120(12):2600-8.
18. Chu CY, Cha ST, Chang CC, Hsiao CH, Tan CT, Lu YC, Jee SH, Kuo ML*. Involvement of matrix metalloproteinase-13 in stromal-cell-derived factor 1 alpha-directed invasion of human basal cell carcinoma cells. Oncogene. 2007 Apr 12;26(17):2491-501.
19. Chang CC, Lin MT, Lin BR, Jeng YM, Chen ST, Chu CY, Chen RJ, Chang KJ, Yang PC, Kuo ML*. Effect of connective tissue growth factor on hypoxia-inducible factor 1alpha degradation and tumor angiogenesis. J Natl Cancer Inst. 2006 Jul 19;98(14):984-95.
20. Su JL, Yang PC, Shih JY, Yang CY, Wei LH, Hsieh CY, Chou CH, Jeng YM, Wang MY, Chang KJ, Hung MC, Kuo ML*. The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells. Cancer Cell. 2006 Mar;9(3):209-23.