​​​​Liu-En.jpg​​Shing-Hwa Liu 
Professor 

TEL : 886-2-23123456#88605
FAX : 886-2-23410217
E-Mail : shinghwaliu@ntu.edu.tw


RESEARCH INTERESTS:

Cellular signaling transduction in toxicology.

Cellular and molecular mechanisms of drugs and toxicants.

Pathophysiological effects and mechanisms of diabetes and inflammation.

 

Personal Files

EDUCATION AND POSITIONS HELD:
●Professor, Institute of Toxicology, College of Medicine, National Taiwan University, 1999-present
●Associate Professor, Institute of Toxicology, College of Medicine, National Taiwan University, 1993-1999
●Instructor, Institute of Toxicology, College of Medicine, National Taiwan University, 1991-1993
●Teaching Assistant, Institute of Pharmacology, College of Medicine, National Taiwan University, 1986-1991

HONORS:
● Annual Research Award at National Science Council, Taiwan (R.O.C.) 1991-2010
● A subject of biographical record in Who’s Who in the World, 2000
● Outstanding Research Award at the Pharmacological Society in Taiwan, 2008

The Research

 

(1987~ present)

  1. SH Liu , WM Fu and SY Lin-Shiau (1987) Mode of contracture inducing action of sodium selenite on the mouse diaphragm. Journal of Formosan Medical Association. 86,579-587.
  2. SY Lin-Shiau, SH Liu, MW Fu and TP Hsu (1987) Reversal by 4-aminopyridine of antagonistic action of uranyl nitrate against b-bungarotoxin in mouse diaphragm. Asia Pacific Journal of Pharmacology. 2,147-153. (SCI)

     
  3. SH Liu, WM Fu and SY Lin-Shiau (1989) Effects of sodium selenite on neuromuscular junction of the mouse phrenic nerve-diaphragm preparation.  Neuropharmacology. 28,733-739. (SCI)
  4. SY Lin-Shiau, SH Liu and WM Fu (1989) Studies on the contracture of the mouse diaphragm induced by sodium selenite. European Journal of Pharmacology.  167,137-146. (SCI)
  5. SY Lin-Shiau, WM Fu, SH Liu and CT Ni (1989) Studies on contractures of mouse diaphragm induced by caffeine, cuppric and selenite ions. Archives Internationales De Pharmacodynamic Et De Therapie. 300,265-280. (SCI)
  6. SY Lin-Shiau, SH Liu and WM Fu (1990) Neuromuscular actions of sodium selenite on chick biventer cervicis nerve-muscule preparation. Neuropharmacology. 29,493-501. (SCI)
  7. SH Liu and SY Lin-Shiau (1992) Studies on mercury-induced myotonia in the mouse diaphragm. Archives Internationales De Pharmacodynamic Et De Therapie. 319,86-100. (SCI) 
  8. SH Liu, WM Fu and SY Lin-Shiau (1993) Studies on the inhibition by chlorpromazine of myotonia induced by ion channel modulators in mouse skeletal muscle. European Journal of Pharmacology. 231,23-30.  (SCI) 
  9. SY Lin-Shiau, SH Liu and MJ Lin (1993) Use of ion channel blockers in exploration of possible mechanism of the diabetic mouse myopathy. Naunyn-Schmiedeberg' Archives Pharmacology. 348,311-318. (SCI)   
  10. WM Fu, SH Yang, SH Liu and SY Lin-Shiau (1993) Roles of innervation and muscle activity on acetylcholine-induced contracture and membrane properties of mouse skeletal muscles. Asia Pacific Journal of Pharmacology.  8,189-197. (SCI) 
  11. SH Liu and S.Y. Lin-Shiau (1994) Potentiation by metal ions of ryanodine contracture of the mouse diaphragm. European Journal of Pharmacology. 251,61-68. (SCI)                                            
  12. WM Fu, SH Yang, SH Liu and SY Lin-Shiau (1994) Influence of muscle activity on the actions of chloride channel blockers in the mouse skeletal muscle. Archives internationales de Pharmacodynamie et de Therapie. 327,96-112. (SCI) 
  13. SH Liu and SY Lin-Shiau (1994) Studies on the contracture inducing action of triphenyltin in the mouse diaphragm. European Journal of Pharmacology.  292,95-101. (SCI)
  14. SH Liu, TJ SHEU, RH Lin and SY Lin-Shiau (1995) The in vivo effect of lipopolysaccharide on the spontaneous release of transmitter from motor nerve terminals. British Journal of Pharmacology. 116,1757-1760. (SCI) 
  15. SH Liu and SY Lin-Shiau (1996) The effects of uranyl ions on neuromuscular transmission in the urinary bladder of the normal and streptozotocin-diabetic mouse. Naunyn-Schmiedeberg' Archives Pharmacology. 354,773-778. (SCI) 
  16. CH Lee, RH Lin, SH Liu and SY Lin-Shiau (1996) Mutual interactions among  ingredients of betel quid in inducing genotoxicity on chinese hamster ovary cells.  Mutation Research. 367,99-104. (SCI) 
  17. KF Chao, SH Liu and SY Lin-Shiau (1996) Suppression of potassium currents by cyanide on the mouse motor nerve terminals. Neuroscience Letters.  203,105-108. (SCI)
  18. SH Liu, JL Lai, RH Lin, MJ Lin and SY Lin-Shiau (1997) Involvement of nitric oxide in the in vivo effects of lipopolysaccharide on the contractile and electrical properties of mouse diaphragm. Naunyn-Schmiedeberg' Archives Pharmacology.   356,500-504. (SCI) 
  19. SH Liu, TJ SHEU, RH Lin and SY Lin-Shiau (1997) The in vivo effect of  lipopolysaccharide on neuromuscular transmission in the mouse. European Journal of  Pharmacology. 333,241-247. (SCI)   
  20. CH Lee, RH Lin, SH Liu and SY Lin-Shiau (1997) Distinct genotoxicity of  phenylmercury acetate in human lymphocytes as compared with other mercury compounds. Mutation Research. 392,269-276. (SCI)  
  21. SH Liu and SY Lin-Shiau (1997) Enhancement by nitric oxide of  neurogenic contraction in the mouse urinary bladder. Naunyn-Schmiedeberg' Archives Pharmacology. 356,850-852 (SCI) 
  22. SH Liu and TJ Sheu (1997) The in vivo effect of lipopolysaccharide on Na+,K+-ATPase catalytic (alpha) subunit isoforms in rat sciatic nerve. Neuroscience Letters. 234,166-168. (SCI)
  23. JJ Kang, SH Liu, IL Chen, YW Cheng and SY Lin-Shiau (1998) Comparative studies on the induction of muscle contracture in mouse diaphragm and Ca2+ release from sarcoplasmic reticulum vesicles by organotin compounds. Pharmacology and Toxicology. 82,23-27. (SCI)
  24. CH Lee, RH Lin, SH Liu and SY Lin-Shiau  (1998) Effects of germanium oxide and other chemical compounds on phenylmercury acetate-induced genotoxicity in cultured human lymphocytes. Environmental and Molecular Mutagenesis. 31,157-162. (SCI)  
  25. MJ Lin, SH Liu and SY Lin-Shiau (1998) Phorbol ester-induced contractions of mouse detrusor muscle are inhibited by nifedipine. Naunyn-Schmiedeberg' Archives Pharmacology. 357,553-557. (SCI)
  26. SH Liu and SY Lin-Shiau (1998) Involvement of nitric oxide in the potentiation of neurogenic contraction by manganese and nickel ions in mouse urinary bladder. Naunyn-Schmiedeberg' Archives Pharmacology. 358,678-681. (SCI)
  27. TK Liu, SH Liu, CH Chang and RS Yang (1998) Concentration of metal elements in the blood and urine in the patients with cementless total knee arthroplasty. Tohoku Journal of Experimental Medicine 185,253-262. (SCI) 
  28. SH Liu, HP Tzeng, ML Kuo and SY Lin-Shiau (1999) Inhibition of inducible nitric oxide synthase by b-lapachone in rat alveolar macrophages and aorta. British Journal of Pharmacology. 126,746-750. (SCI)
  29. SH Liu, JH Wang, KT Fang and SY Lin-Shiau (1999) Involvement of protein kinase C in the nitric oxide-mediated peripheral nerve disturbance in endotoxemic rats. Neuroscience Letters. 259,99-102. (SCI)
  30. FM Ho, SH Liu, CS Liau, PJ Huang, SG Shiah and SY Lin-Shiau (1999) Nitric oxide prevents apoptosis of human endothelial cells from high glucose exposure during early stage. Journal of Cellular Biochemistry. 75,258-263. (SCI)
  31. SH Liu*, JH Wang, JJ Kang, RH Lin and SY Lin-Shiau (2000) Alterations in the properties and isoforms of sciatic nerve Na,K-ATPase in methylcyclopentadienyl manganese tricarbonyl-treated mice. Environmental Research. 82,239-244. (SCI)
  32. FM Ho, SH Liu, CS Liau, PJ Huang and SY Lin-Shiau* (2000) High glucose-induced apoptosis in human endothelial cells is mediated by sequential activation of c-Jun NH2-terminal kinase and caspase-3. Circulation 101,2618-2624. (SCI)
  33. JW Liao, JJ Kang, SH Liu, CR Jeng, YW Cheng, CM Hu, SF Tsai, SC Wang and VF Pang* (2000) Effects of cartap on isolated mouse phrenic nerve diaphragm and its related mechanism. Toxicological Science. 55,453-459. (SCI)
  34. SH Liu* and SY Lin-Shiau (2000) Protein kinase C regulates purinergic component of neurogenic contractions in mouse urinary bladder. Journal of Urology. 164,1764-1767. (SCI)
  35. SH Chen, SH Liu, YC Liang, JK Lin and SY Lin-Shiau* (2000) Death signaling pathway induced by pyrrolidine dithiocarbamate/Cu2+ complex in the cultured rat cortical astrocytes. Glia. 31,249-261. (SCI)
  36. BS Wang, YJ Chen, SH Liu and SY Lin-Shiau* (2000) An increase in free radical production by means of an anion channel blocker DIDS in mouse peritoneal neutrophils. Proceedings of the National Science Council, ROC. 24,178-186.
  37. SH Chen, SH Liu, YC Liang, JK Lin and SY Lin-Shiau* (2001) Oxidative stress and c-Jun-amino-terminal kinase activation involved in apoptosis of primary astrocytes induced by disulfiram-Cu2+ complex. European Journal of Pharmacology. 414,177-188. (SCI)
  38. NL Shih, TH Cheng, SH Loh, PY Cheng, DL Wang, YS Chen, SH Liu, CC Liew, JJ Chen* (2001) Reactive Oxygen Species Modulate Angiotensin II-Induced beta-Myosin Heavy Chain Gene Expression via Ras/Raf/Extracellular Signal-Regulated Kinase Pathway in Neonatal Rat Cardiomyocytes. Biochemical and Biophysical Research Communications 283,143-148. (SCI)
  39. JJ Chuu, YH Young, SH Liu and SY Lin-Shiau* (2001) Neurotoxicity of mercury sulfide in the vestibular ocular reflex system of guinea-pigs. Naunyn-Schmiedebergs Archives of Pharmacology. 364,249-258. (SCI)
  40. JJ Chuu, SH Liu and SY Lin-Shiau* (2001) Effects of methyl mercuric sulfide and cinnabar on active avoidance responses, Na+/K+-ATPase activities and tissue mercury contents in rats. Proceedings of the National Science Council, ROC. 25,128-136. (SCI)
  41. CT Tan, SY Lee, CJ Yao, SH Liu and SY Lin-Shiau* (2001) Effects of gentamicin and pH on [Ca2+]i in apical and basal outer hair cells from guinea pigs. Hearing Research 154,81-87. (SCI)
  42. CT Tan, CJ Hsu, SY Lee, SH Liu and SY Lin-Shiau* (2001) Potentiation of noise-induced hearing loss by amikacin in guinea pigs. Hearing Research 161,72-80. (SCI)
  43. YH Young , JJ Chuu, SH Liu and SY Lin-Shiau* (2001) Toxic effects of potassium bromate and thioglycolate on vestibuloocular reflex systems of guinea pigs and humans. Toxicology and Applied Pharmacology 177,103-111.
  44. TH Cheng, NL Shih, SY Che, SH Loh, PY Cheng, CS Tsai, SH Liu, DL Wang, JJ Chen* (2001) Reactive oxygen species mediate cyclic strain-induced endothelin-1 gene expression via ras/raf/extracellular signal-regulated kinase pathway in endothelial cells. Journal of Molecular and Cellular Cardiology 33:1805-1814. (SCI)
  45. TH Huang, RS Yang, SS Hsieh, SH Liu. (2002) Effects of caffeine and exercise on the development of bone: a densitometric and histomorphometric study in young wistar rats. Bone 30:293-299. (SCI)
  46. SH Liu*, JH Wang, JJ Chuu and SY Lin-Shiau (2002) Alterations of motor nerve functions in animals exposed to motorcycle exhaust. Journal of Toxicology and Environmental Health part A 65:803-812. (SCI)
  47. SH Liu* and SY Lin-Shiau (2002) Mercuric chloride alters the membrane potential and intracellular calcium level in mouse pancreatic islet cells. Journal of Toxicology and Environmental Health part A 65:317-326. (SCI)
  48. RS Yang, CH Tang, QD Ling, SH Liu and WM Fu (2002) Regulation of fibronectin fibrillogenesis by protein kinases in cultured rat osteoblasts. Molecular Pharmacology 61:1163-1173. (SCI)
  49. YH Young , JJ Chuu, SH Liu and SY Lin-Shiau (2002) Neurotoxic mechanism of cinnabar and mercuric sulfide on the vestibulo-ocular reflex system of guinea pigs. Toxicological Sciences 67:256-263. (SCI)
  50. SH Liu*, JL Lai, RS Yang and SY Lin-Shiau (2002) Nitric oxide is not involved in the endotoxemia-induced alterations in Ca2+ and ryanodine responses in mouse diaphragms. Naunyn-Schmiedebergs Archives of Pharmacology 366:327-334. (SCI)
  51. Yen CC, Liu SH, Chen WK, Lin RH, Lin-Shiau SY. (2002) Tissue distribution of different mercurial compounds analyzed by the improved FI-CVAAS. J Anal Toxicol 26:286-295. (SCI)
  52. RS Yang, YH Chen, SY Lin-Shiau, TK Liu and SH Liu* (2003) The role of titanium in the altered endotoxin-induced nitric oxide synthase expression in alveolar macrophages from titanium alloy implanted rats. Journal of Biomedical Materials Research. 66A:802-810. (SCI)
  53. Huang TH, Lin SC, Chang FL, Hsieh SS, Liu SH, Yang RS (2003) The effects of different exercise modes on mineralization, structure and biomechanical properties of growing bone. Journal of Applied Physiology 95:300-307. (SCI)
  54. Tzeng HP, Yang RS, Ueng TH, Lin-Shiau SY, Liu SH* (2003) Motorcycle exhaust particulates enhance vasoconstriction in organ culture of rat aortas and involve reactive oxygen species. Toxicological Sciences 75:66-73. (SCI)
  55. Tzeng HP, Ho FM, Chao KF, Kuo ML, Lin-Shiau SY, Liu SH* (2003) beta-Lapachone reduces endotoxin-induced macrophage activation and lung edema and mortality. American Journal of Respiratory and Critical Care Medicine 168:85-91. (SCI)
  56. RS Yang, KS Tsai and SH Liu* (2004) Titanium implants enhance pulmonary nitric oxide production and lung injury in rats related to endotoxin. Journal of Biomedical Materials Research 69A:561-566. (SCI)
  57. KS Tsai, RS Yang, and SH Liu* (2004) Benzo[a]pyrene regulates osteoblast proliferation through an estrogen receptor-related cyclooxygenases-2 pathway. Chemical Research in Toxicology 17:679-684. (SCI)
  58. ML Sheu, FM Ho, KF Chao, ML Kuo, and SH Liu* (2004) Activation of phosphoinositide 3-kinase in response to high glucose leads to regulation of reactive oxygen species-related nuclear factor-κB activation and cyclooxygenases-2 expression in mesangial cells. Molecular Pharmacology 66: 187-196 (SCI)
  59. Chiang CK, Hsu SP, Pai MF, Peng YS, Ho TI, Liu SH*, Hung KY, Tsai TJ. (2004) Interleukin-18 is a strong predictor of hospitalization in haemodialysis patients. Nephrology Dialysis Transplantation 19:2810-2815. (SCI) (co-corresponding author)
  60. Tang CH, Yang RS, Huang TH, Liu SH, Fu WM. (2004) Enhancement of Fibronectin Fibrillogenesis and Bone Formation by Basic Fibroblast Growth Factor via Protein Kinase C-Dependent Pathway in Rat Osteoblasts. Molecular Pharmacology 66:440-449. (SCI)
  61. Huang TS, Yang RS, Tsai TW, Liu SH. (2004) Growth hormone cannot enhance the recovery of dexamethasone-induced osteopenia after withdrawal in young female wistar rats. Tohoku Journal of Experimental Medicine 204:257-266. (SCI)
  62. ML Sheu, KF Chao, YJ Sung, WW Lin, SY Lin-Shiau and SH Liu*. (2005) Activation of phosphoinositide 3-kinase in response to inflammation and nitric oxide leads to the up-regulation of cyclooxygenase-2 expression and subsequent cell proliferation in mesangial cells. Cellular Signalling 17:975-984 (SCI)
  63. Tzeng HP, Chiang W, Ueng TH, and Liu SH*. (2005) The abortifacient effects from the seeds of Coix lachryma-jobi L. var. ma-yuen Stapf. Journal of Toxicology and Environmental Health part A 68:1557-1565 (SCI)
  64. ML Sheu, FM Ho, RS Yang, KF Chao, WW Lin, SY Lin-Shiau, SH Liu* (2005) High glucose induces human endothelial cell apoptosis through a phosphoinositide 3-kinase-regulated cyclooxygenase-2 pathway. Arteriosclerosis, Thrombosis, and Vascular Biology 25:539-545 (SCI)
  65. Chiang CK, Hsu SP, Pai MF, Peng YS, Ho TI, Liu SH*, Hung KY, Tsai TJ, Hsieh BS. (2005) Plasma interleukin-18 levels in chronic renal failure and continuous ambulatory peritoneal dialysis. Blood Purification 23:144-148 (SCI) (co-corresponding author)
  66. TI Weng, WJ Chen, and SH Liu*. (2005) Bladder instillation of Escherichia coli lipopolysaccharide alters the muscle contractions in rat urinary bladder via a protein kinase C-related pathway. Toxicology and Applied Pharmacology 208:163-169 (SCI)
  67. Cheng PW, Liu SH, Hsu CJ, Lin-Shiau SY. (2005) Correlation of increased activities of Na(+), K(+)-ATPase and Ca(2+)-ATPase with the reversal of cisplatin ototoxicity induced by d-methionine in guinea pigs. Hearing Research 205(1-2):102-109 (SCI)
  68. KC Chao, KF Chao, CC Chuang and SH Liu* (2006) Blockade of interleukin-6 accelerates acinar cell apoptosis and attenuates experimental acute pancreatitis in vivo. British Journal of Surgery 93:332-338. (SCI)
  69. Chiang CK, Huang JW, Hsu SP, Ho TI, Pai MF, Peng YS, Liu SH*, Hung KY, Tsai TJ. (2006) Plasma interleukin-18 levels in hemodialysis patients: increased by dialysis process and association with interleukin-6 and tumor necrotic factor-alpha. Blood Purification 24:174-179. (SCI) (co-corresponding author)
  70. Ho FM, Lin WW, Chen BC, Chao CM, Yang CR, Lin LY, Lai CC, Liu SH, Liau CS. (2006) High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-kappaB and c-Jun NH(2)-terminal kinase pathway and prevented by PI3K/Akt/eNOS pathway. Cellular Signalling 18:391-399. (SCI)
  71. Chen YW, Huang CF, Tsai KS, Yang RS, Yen CC, Yang CY, Lin-Shiau SY, Liu SH* (2006) The role of phosphoinositide 3-kinase/Akt signaling in low-dose mercury-induced mouse pancreatic b cell dysfunction in vitro and in vivo. Diabetes 55:1614-1624. (SCI)
  72. Cheng PW, Liu SH, Young YH, Lin-Shiau SY. (2006) d-Methionine attenuated cisplatin-induced vestibulotoxicity through altering ATPase activities and oxidative stress in guinea pigs. Toxicology and Applied Pharmacology 215:228-236 (SCI)
  73. Chiang CK, Sheu ML, Hung KY, Wu KD, and Liu SH* (2006) Honokiol, a small molecular weight natural product, alleviates experimental mesangial proliferative glomerulonephritis. Kidney International 70:682-689. (SCI)
  74. Chen YW, Huang CF, Tsai KS, Yang RS, Yen CC, Yang CY, Lin-Shiau SY, and Liu SH* (2006) Methylmercury induces pancreatic b-cell apoptosis and dysfunction. Chemical Research in Toxicology 19:1080-1085. (SCI)
  75. Weng TI, Chen WJ, Wu HY and Liu SH* (2006) Uropathogenic Escherichia coli Alters the Muscle Contractions in Rat Urinary Bladder via a Nitric Oxide Synthase-Related Signaling Pathway. The Journal of Infectious Diseases 194:1774-1782. (SCI)
  76. Ho FM, Liu SH, Lin WW, Liau CS. (2007) Opposite Effects of High Glucose on MMP-2 and TIMP-2 in Human Endothelial Cells. Journal of Cellular Biochemistry 101:442-450. (SCI)
  77. Chuu JJ, Liu SH, Lin-Shiau SY. (2007) Differential neurotoxic effects of methylmercury and mercuric sulfide in rats. Toxicology Letters 169:109-120. (SCI)
  78. Chuang CC, Yang RS, Tsai KS, Ho FM, and Liu SH*. (2007) Hyperglycemia enhances adipogenic induction of lipid accumulation: involvement of extracellular signal-regulated protein kinase 1/2, phosphoinositide 3-kinase/AKT and peroxisome proliferator-activated receptor-g (PPAR-g) signaling. Endocrinology 148:4267-4275.  (SCI)
  79. Tzeng HP, Yang RS, Ueng TH, Liu SH* (2007) Up-regulation of cyclooxygenase-2 by motorcycle exhaust particulates-induced reactive oxygen species enhances rat vascular smooth muscle cell proliferation. Chemical Research in Toxicology 20:1170-1176. (SCI)
  80. Yen CC, Lu FJ, Huang CF, Chen WK, Liu SH, Lin-Shiau SY (2007) The diabetogenic effects of the combination of humic acid and arsenic: In vitro and in vivo studies. Toxicology letters 172:91-105. (SCI)
  81. Chen CM, Liu SH, Lin-Shiau SY. (2007) Honokiol, a neuroprotectant against mouse cerebral ischaemia, mediated by preserving Na(+), K(+)-ATPase activity and mitochondrial functions. Basic and Clinical Pharmacology and Toxicology 101:108-116. (SCI)
  82. Huang CF, Liu SH, Lin-Shiau SY. (2007) Neurotoxicological effects of cinnabar (a Chinese mineral medicine, HgS) in mice. Toxicology and Applied Pharmacology 224:192-201. (SCI)
  83. Sheu ML, Liu SH*, Lan KH. (2007) Honokiol induces calpain-mediated glucose-regulated protein-94 cleavage and apoptosis in human gastric cancer cells and reduces tumor growth. PLoS ONE 2 (10): e1096. (SCI)
  84. Lan KC, Ma T, Lin-Shiau SY, Liu SH, Ho IK. (2007) Methamphetamine-elicited alterations of dopamine- and serotonin-metabolite levels within mu-opioid receptor knockout mice: a microdialysis study. Journal of Biomedical Science 15:391-403. (SCI)
  85. Chen SH, Lin JK, Liu SH, Liang YC, Lin-Shiau SY. (2008) Apoptosis of cultured astrocytes induced by the copper and neocuproine complex through oxidative stress and jnk activation. Toxicological Sciences 102:138-149. (SCI)
  86. Huang CF, Hsu CJ, Liu SH, Lin-Shiau SY. (2008) Neurotoxicological mechanism of methylmercury induced by low-dose and long-term exposure in mice: Oxidative stress and down-regulated Na(+)/K(+)-ATPase involved. Toxicology Letters 176:188-197. (SCI)
  87. Chao KC, Chao KF, Fu YS, and Liu SH*. (2008) Islet-like clusters derived from mesenchymal stem cells in wharton's jelly of the human umbilical cord for transplantation to control type 1 diabetes. PLoS ONE 3(1):e1451. (SCI)
  88. Cheng PW, Liu SH, Young YH, Hsu CJ, Lin-Shiau SY. (2008) Protection from Noise-Induced Temporary Threshold Shift by d-Methionine is Associated with Preservation of ATPase Activities. Ear Hear 29:65-75. (SCI)
  89. Yang RS, Chiang W, Lu YH, and Liu SH*. (2008) Evaluation of osteoporosis prevention by adlay using a tissue culture model. Asia Pacific Journal of Clinical Nutrition 17 (S1):143-146. (SCI)
  90. Chao KC, Chao KF, Chen CF, Liu SH* (2008) A novel human stem cell-co-culture system that maintains the survival and function of culture islet-like cell clusters. Cell Transplantation 17:657-664. (SCI)
  91. Huang CF, Hsu CJ, Liu SH, Lin-Shiau SY. (2008) Ototoxicity induced by cinnabar (a naturally occurring HgS) in mice through oxidative stress and down-regulated Na(+)/K(+)-ATPase activities. Neurotoxicology 29:386-396. (SCI)
  92. Sheu ML, Chiang CK, Tsai KS, Ho FM, Weng TI, Wu HY, Liu SH* (2008) Inhibition of NADPH oxidase-related oxidative stress-triggered signaling by honokiol suppresses high glucose-induced human endothelial cell apoptosis. Free Radical Biology and Medicine 44:2043-2050. (SCI)
  93. Chen CM, Lin JK, Liu SH, Lin-Shiau SY. (2008) Novel regimen through combination of memantine and tea polyphenol for neuroprotection against brain excitotoxicity. Journal of Neuroscience Research 86:2696-2704. (SCI)
  94. Huang TH, Chang FL, Lin SC, Liu SH, Hsieh SS, Yang RS. (2008) Endurance treadmill running training benefits the biomaterial quality of bone in growing male Wistar rats. Journal of Bone and Mineral Metabolism 26:350-357. (SCI)
  95. Chen SH, Lin JK, Liang YC, Pan MH, Liu SH, Lin-Shiau SY. (2008) Involvement of activating transcription factors JNK, NF-kB, and AP-1 in apoptosis induced by pyrrolidine dithiocarbamate/Cu complex. European Journal of Pharmacology 594:9-17. (SCI)
  96. Yang RS, Liu SH*. (2009) Current pharmacological approaches to prevent and treat post-menopausal osteoporosis. Recent Patents on Endocrine, Metabolic & Immune Drug Discovery 3:42-53. (Invited Review Article)
  97. Lan KC, Chang AC, Liu SH, Ho IK, Lin-Shiau Shoei-Yn. (2009) Enhancing effects of morphine on methamphetamine-induced reinforcing behavior and its association with dopamine release and metabolism in mice. Journal of Neurochemistry 109:382-392. (SCI)
  98. Leu YL, Chen YW, Yang CY, Huang CF, Lin GH, Tsai KS, Yang RS, Liu SH* (2009) Extract isolated from Angelica hirsutiflora with insulin secretagogue activity. Journal of Ethnopharmacology 123:208-212. (SCI)
  99. Yang RS, Tzeng HP, Ho FM, Chuang CC, Chen BL, Huang CF, Chen YW, Chen RM, Liu SH* (2009) Titanium implants alter endothelial function and vasoconstriction via a protein kinase C-regulated pathway. Acta Biomaterialia 5:3258-3264. (SCI)
  100. Chen YJ , Wei YY, Chen HT, Fong YC, Hsu CJ, Tsai CH, Hsu HC, Liu SH*, Tang CH. (2009) Osteopontin increases migration and mmp-9 up-regulation via avb3 integrin, fak, erk, and NF-kB-dependent pathway in human chondrosarcoma cells. Journal of Cellular Physiology 221:98-108. (SCI)
  101. Weng TI, Wu HY, Lin PY, Liu SH* (2009) Uropathogenic Escherichia coli-induced inflammation alters mouse urinary bladder contraction via an interleukin-6-activated inducible nitric oxide synthase-related pathwaysynthase-related signaling pathway. Infection and Immunity 77:3312-3319. (SCI)
  102. Chen YW, Yang CY, Huang CF, Hung DZ, Leung YM, Liu SH* (2009) Heavy metals and islet function and diabetes development. Islets 1:1-8. (SCI) (Invited Review Article)
  103. Yang FY; Chiu WH, Liu SH, Lin GL, Ho FM (2009) Functional changes in arteries induced by pulsed high intensity focused ultrasound. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 56:2643-9. (SCI)
  104. Yang FY, Liu SH, Ho FM, Chang CH (2009) Effect of ultrasound contrast agent dose on the duration of focused-ultrasound-induced blood-brain barrier disruption. Journal of the Acoustical Society of America 126:3344-9. (SCI)
  105. Chen YW, Huang CF, Yang CY, Yen CC, Tsai KS, Liu SH* (2010) Inorganic mercury causes pancreatic b-cell death via the oxidative stress-induced apoptotic and necrotic pathways. Toxicology and Applied Pharmacology 243:323-31. (SCI)
  106. Huang TH, Hsieh SS, Liu SH, Chang FL, Lin SC, Yang RS (2010) Swimming training increases the post-yield energy of bone in young male rats. Calcified Tissue International 86:142-53. (SCI)
  107. Chen YJ, Wu CL, Liu JF, Fong YC, Hsu SF, Li TM, Su YC, Liu SH*, Tang CH (2010) Honokiol induces cell apoptosis in human chondrosarcoma cells through mitochondrial dysfunction and endoplasmic reticulum stress. Cancer Letters 291:20-30. (SCI)
  108. Liu SH, Yang CN, Pan HC, Sung YJ, Liao KK, Chen WB, Lin WZ, and Sheu ML (2010) IL-13 down-regulates PPAR-g/heme oxygenase-1 via ER stress-stimulated calpain activation: aggravation of activated microglia death. Cellular and Molecular Life Sciences 67:1465-76. (SCI)
  109. Yang FY, Chiu WH, Liu SH, Ho FM (2010) The length ratios between fetal limb bones and nasal bone in the general population. European Journal of Obstetrics & Gynecology and Reproductive Biology 148:99-100. (SCI)
  110. Lin TH, Tang CH, Hung SY, Liu SH, Lin YM, Fu WM, Yang RS. (2010) Upregulation of heme oxygenase-1 inhibits the maturation and mineralization of osteoblasts. Journal of Cellular Physiology 222:757-68. (SCI)
  111. Wu CT, Sheu ML, Tsai KS, Weng TI, Chiang CK, Liu SH* (2010) The role of endoplasmic reticulum stress-related unfolded protein response in the radiocontrast medium-induced renal tubular cell injury. Toxicological Sciences 114:295-301. (SCI)
  112. Yen YP, Tsai KS, Chen YW, Huang CF, Yang RS, Liu SH* (2010) Arsenic inhibits myogenic differentiation and muscle regeneration. Environmental Health Perspectives 118:949-956. (SCI)
  113. Liu SH, Shen CC, Yi YC, Tsai JJ, Wang CC, Chueh JT, Lin KL, Lee TC, Pan HC, Sheu ML (2010) Honokiol inhibits gastric tumorigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of PPAR-g and COX-2 dependent signals. British Journal of Pharmacology 160:1963-72. (SCI)
  114. Yang TH, Liu SH, Young YH (2010) A novel inner ear monitoring system for evaluating ototoxicity of gentamicin eardrops in guinea pigs. Laryngoscope 120:1220-6. (SCI)
  115. Liu SH, Chang YH, Chiang MT (2010) Chitosan reduces gluconeogenesis and increases glucose uptake in skeletal muscle in streptozotocin-induced diabetic rats. Journal of Agricultural and Food Chemistry 58:5795-800. (SCI)
  116. Yang TH, Liu SH, Wang SJ, Young YH (2010) An animal model of ocular vestibular-evoked myogenic potential in guinea pigs. Experimental Brain Research 205:145-52. (SCI)
  117. Yang TH, Liu SH, Young YH (2010) Evaluation of guinea pig model for ocular and cervical vestibular-evoked myogenic potentials for vestibular function test. Laryngoscope 120:1910-7. (SCI)
  118. Chen CM, Lin JK, Liu SH, Lin-Shiau SY (2010) Characterization of neurotoxic effects of NMDA and the novel neuroprotection by phytopolyphenols in mice. Behavioral Neuroscience 124:541-53. (SCI)
  119. Yang TH, Young YH, Liu SH* (2011) EGb 761 (Ginkgo biloba) protects cochlear hair cells against ototoxicity induced by gentamicin via reducing reactive oxygen species and nitric oxide-related apoptosis. Journal of Nutritional Biochemistry 22:886-894. (SCI)
  120. Weng TI, Wu HY, Kuo CW, Liu SH* (2011) Honokiol rescues sepsis-associated acute lung injury and lethality via the inhibition of oxidative stress and inflammation. Intensive Care Medicine 37:533-41. (SCI)
  121. Liu SH, Chen C, Yang RS, Yen YP, YangYT, Tsai C (2011) Caffeine enhances osteoclast differentiation from bone marrow hematopoietic cells and reduces bone mineral density in growing rats. Journal of Orthopaedic Research 29:954-60. (SCI)
  122. Huang CF, Chen YW, Yang, CY, Lin, HY, Way TD, Chiang W, Liu SH* (2011) Extract of Lotus Leaf (Nelumbo nucifera) and Its Active Constituent Catechin with Insulin Secretagogue Activity. Journal of Agricultural and Food Chemistry 59:1087-94. (SCI)
  123. Chiang CK, Sheu ML, Lin YW, Wu CT, Yang CC, Chen MW, Hung KY, Wu KD, Liu SH* (2011) Honokiol ameliorates renal fibrosis by inhibiting extracellular matrix and proinflammatory factors in vivo and in vitro. British Journal of Pharmacology 163:586-97. (SCI)
  124. Lu TH, Su CC, Chen YW, Yang CY, Wu CC, Hung DZ, Chen CH, Cheng PW, Liu SH#, Huang CF (2011) Arsenic induces pancreatic b-cell apoptosis via the oxidative stress-regulated mitochondria-dependent and endoplasmic reticulum stress-triggered signaling pathways. Toxicology Letters 201:15-26. (SCI) (#: equal first-author)
  125. Huang CF, Liu SH, Hsu CJ, Lin-Shiau SY (2011) Neurotoxicological effects of low-dose methylmercury and mercuric chloride in developing offspring mice.  Toxicology Letters 201:196-204. (SCI)
  126. Yen CC, Ho TJ, Wu CC, Chang CF, Su CC, Chen YW, Jinn TR, Lu TH, Cheng PW, Su YC, Liu SH*, Huang CF* (2011) Inorganic arsenic causes cell apoptosis in mouse cerebrum through an oxidative stress-regulated signaling pathway. Archives of Toxicology 85:565-575. (SCI)
  127. Lu TH, Hsieh SY, Yen CC, Wu HC, Chen KL, Hung DZ, Chen CH, Wu CC, Su YC, Chen YW, Liu SH*, Huang CF* (2011) Involvement of oxidative stress-mediated ERK1/2 and p38 activation regulated mitochondria-dependent apoptotic signals in methylmercury-induced neuronal cell injury. Toxicology Letters 204:71-80. (SCI)
  128. Wu CT, Sheu ML, Tsai KS, Chiang CK, Liu SH* (2011) Salubrinal, an eIF2a dephosphorylation inhibitor, enhances cisplatin-induced oxidative stress and nephrotoxicity in a mouse model. Free Radical Biology & Medicine 51:671-80. (SCI)
  129. Huang CF, Chen YW, Yang CY, Tsai KS, Yang RS, Liu SH* (2011) Arsenic and Diabetes: Current Perspectives. Kaohsiung Journal of Medical Sciences 27:402-10. (SCI)
  130. Hsu CK, Liao MH, Tai YT, Liu SH, Ou KL, Fang HW, Lee IJ, Chen RM (2011) Nanoparticles prepared from the water extract of Gusuibu (Drynaria fortunei J. Sm.) protects osteoblasts against insults and promotes cell maturation. International Journal of Nanomedicine 6:1405-1413. (SCI)
  131. Tsai JJ, Liu SH#, Yin SC, Yang CN, Hsu HS, Chen WB, Liao EC, Lee WJ, Pan HC, Sheu ML (2011) Mite allergen Der-p2 triggers human B lymphocyte activation and toll-like receptor-4 induction. PLoS ONE 6(9):e23249. (SCI) (#: equal first-author)
  132. Huang CF, Yang RS, Liu SH, Hsieh PC, Lin-Shiau SY (2011) Evidence for improved neuropharmacological efficacy and decreased neurotoxicity in mice with traditional processing of rhizoma arisaematis. American Journal of Chinese Medicine 39:981-98. (SCI)
  133. Chiang CK, Hsu SP, Wu CT, Huang JW, Cheng HT, Chang YW, Hung KY, Wu KD, Liu SH* (2011) Endoplasmic Reticulum Stress Implicated in the Development of Renal Fibrosis. Molecular Medicine 17:1295-1305 (SCI)
  134. Huang KH, Weng TI, Huang HY, Huang KD, Lin WC, Chen SC, Liu SH* (2012) Honokiol Attenuates Torsion/Detorsion-Induced Testicular Injury in Rat Testis via Suppressing Endoplasmic Reticulum Stress-Related Apoptosis. Urology 79:967.e5-967.e11. (SCI)
  135. Weng TI, Wu HY, Chen BL, Liu SH* (2012) Honokiol attenuates the severity of acute pancreatitis and associated lung injury via acceleration of acinar cell apoptosis. Shock 37:478-84. (SCI)
  136. Huang KH, Kuo KL, Chen SC, Weng TI, Chuang YT, Tsai YC, Pu YS, Chiang CK, Liu SH* (2012) Down-regulation of glucose-regulated protein (GRP)78 potentiates cytotoxic effect of celecoxib in human urothelial carcinoma cells. PLoS ONE 7(3):e33615. (SCI)
  137. Liu SH, He SP, Chiang MT (2012) Effects of long-term feeding of chitosan on postprandial lipid responses and lipid metabolism in a high-sucrose diet-impaired glucose tolerance rat model. Journal of Agricultural and Food Chemistry 60:4306-13. (SCI)
  138. Yen YP, Tsai KS, Chen YW, Huang CF, Yang RS, Liu SH* (2012) Arsenic induces apoptosis in myoblasts through a reactive oxygen species-induced endoplasmic reticulum stress and mitochondrial dysfunction pathway. Archives of Toxicology 86:923-33. (SCI)
  139. Huang CF, Hsu CJ, Liu SH, Lin-Shiau SY (2012) Exposure to low-dose of cinnabar (a naturally occurring mercuric sulfide (HgS)) caused neurotoxicological effects in offspring mice. Journal of Biomedicine and Biotechnology 2012:254582. (SCI)
  140. Chen CM, Wu CT, Chiang CK, Liao BW, Liu SH* (2012) C/EBP homologous protein (CHOP) deficiency aggravates hippocampal cell apoptosis and impairs memory performance. PLoS ONE 7(7):e40801. (SCI)
  141. Liu SH, Wang KB, Lan KH, Lee WJ, Pan HC, Wu SM, Peng YC, Chen YC, Shen CC, Cheng HC, Liao KK, Sheu ML (2012) Calpain/SHP-1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nu/nu mice. PLoS ONE 7(8): e43711. (SCI)
  142. Chen KL, Liu SH#, Su CC, Yen CC, Yang CY, Lee KI, Tang FC, Chen YW, Lu TH, Su YC, Huang CF (2012) Mercuric Compounds Induce Pancreatic Islets Dysfunction and Apoptosis in Vivo. International Journal of Molecular Sciences 13:12349-12366. (SCI) (#: equal first-author)
  143. Huang CF, Liu SH, Lin-Shiau SY (2012) Pyrrolidine dithiocarbamate augments Hg(2+)-mediated induction of macrophage cell death via oxidative stress-induced apoptosis and necrosis signaling pathways. Toxicology Letters 214:33-45. (SCI)
  144. Wang CC, Weng TI, Wu ET, Wu MH, Yang RS, Liu SH* (2013) Involvement of interleukin-6-regulated nitric oxide synthase in hemorrhagic cystitis and impaired bladder contractions in young rats induced by acrolein, a urinary metabolite of cyclophosphamide. Toxicological Sciences 131:302-310. (SCI)
  145. Hsu FL, Huang CF, Chen YW, Yen YP, Wu CT, Uang BJ, Yang RS, Liu SH* (2013) Anti-diabetic effects of pterosin A, a small molecular weight natural product, on diabetic mouse models. Diabetes 62:628-638. (SCI)
  146. Chen YF, Huang WY, Chen SC, Guo YJ, Lan CF, Liu SH, Huang KH (2013). Factors associated with delayed pediatric hypospadias surgery in Taiwan: a population-based nationwide analysis. Journal of the Formosan Medical Association 112:48-53. (SCI)
  147. Wu CT, Weng TI, Chen LP, Chiang CK, Liu SH* (2013) Involvement of caspase-12-dependent apoptotic pathway in ionic radiocontrast urografin-induced renal tubular cell injury. Toxicology and Applied Pharmacology 266: 167-175. (SCI)
  148. Shen YC, Ou DL, Hsu C, Lin KL, Chang CY, Lin CY, Liu SH*, Cheng AL* (2013) Activating Oxidative Phosphorylation by a Pyruvate Dehydrogenase Kinase Inhibitor Overcomes Sorafenib Resistance of Hepatocellular Carcinoma. British Journal of Cancer 108:72-81. (SCI)
  149. Chang KC, Hsu CC, Liu SH#, Su CC, Yen CC, Lee MJ, Chen KL, Ho TJ, Hung DZ, Wu CC, Lu TH, Su YC, Chen YW, Huang CF (2013) Cadmium Induces Apoptosis in Pancreatic β-Cells through a Mitochondria-Dependent Pathway: The Role of Oxidative Stress-Mediated c-Jun N-Terminal Kinase Activation. PLoS ONE 8(2):e54374. (SCI) (#: equal first-author)
  150. Liu SH, Sheu WHH, Lee MR, Lee WJ, Yi YC, Yang TJ, Jen JF, Pan HC, Shen CC, Chen WB, Tien HR, Sheu ML (2013) Advanced glycation endproduct Nε-carboxymethyllysine induces endothelial cell injury: Role of tyrosine phosophatase SHP-1-regulated VEGFR-2 (KDR/Flk-1) dephosphorylation through NADPH oxidase-derived reactive oxygen species. Journal of Pathology 230:215-27. (SCI)
  151. Che YJ, Tsai KS, Chiu CY, Yang TH, Lin TH, Fu WM, Chen CF, Yang RS, Liu SH* (2013) EGb761 Inhibits Inflammatory Responses in Human Chondrocytes and Shows Chondroprotection in Osteoarthritic Rat Knee. Journal of Orthopedic Research 31:1032-1038. (SCI)
  152. Yang RS, Lu YH, Chiang W, Liu SH* (2013) Osteoporosis prevention by adlay (the seeds of Coix lachryma-jobi L. var. ma-yuen Stapf) in a mouse model. Journal of Traditional and Complementary Medicine 3:134-138.
  153. Liu SH, Huang YW, Wu CT, Chiu CY, Chiang MT (2013) Low molecular weight chitosan accelerates glucagon-like peptide-1 secretion in the human intestinal endocrine cells via a p38-dependent pathway. Journal of Agricultural and Food Chemistry 61:4855-4861. (SCI)
  154. Chen YJ, Sheu ML, Tsai KS, Yang RS, Liu SH* (2013) Advanced glycation end products induce peroxisome proliferator-activated receptor γ down-regulation-related inflammatory signals in human chondrocytes via toll-like receptor-4 and receptor for advanced glycation end products. PLoS ONE 8(6):e66611. (SCI)
  155. Huang KH, Kuo KL, Ho IL, Chang HC, Chuang YT, Lin WC, Lee PY, Chang SC, Chiang CK, Pu YS, Chou CT, Hsu CH, Liu SH* (2013) Celecoxib-induced cytotoxic effect is potentiated by inhibition of autophagy in human urothelial carcinoma cells. PLoS ONE 8(12): e82034. (SCI)
  156. Wang LT, Chen BL, Wu CT, Huang KH, Chiang CK, Liu SH* (2013) Protective role of AMP-activated protein kinase-evoked autophagy on an in vitro model of ischemia/reperfusion-induced renal tubular cell injury. PLoS ONE 8(11): e79814. (SCI)
  157. Yang CC, Wu CT, Chen LP, Hung KY, Liu SH*, Chiang CK* (2013) Autophagy induction promotes aristolochic acid-I-induced renal injury in vivo and in vitro. Toxicology 312: 63-73. (SCI)
  158. Weng TI, Wu HY, Chen BL, Jhuang JY, Huang KH, Chiang CK, Liu SH* (2013) C/EBP homologous protein (CHOP) deficiency aggravates acute pancreatitis and associated lung injury. World Journal of Gastroenterology 19:7097-105. (SCI)
  159. Wang CC, Weng TI, Lu MY, Yang RS, Lin KH, Wu MH, Liu SH* (2015) Hemorrhagic cystitis in children treated with alkylating agent cyclophosphamide: the experience of a medical center in Taiwan. Journal of the Formosan Medical Association 114:691-697. (SCI)
  160. Chen RM, Liao MH, Tai YT, Cherng YG, Liu SH, Chang YA, Lin PI (2014) Genistein induces estrogen receptor-α gene expression in osteoblasts through activation of MAPKs/NF-κB/AP-1 and promotes cell mineralization. British Journal of Nutrition  5:1-9. (SCI)
  161. Chen YJ, Tsai KS, Chan DC, Lan KC, Chen CF, Yang RS, Liu SH* (2014) Honokiol, a low molecular weight natural product, prevents inflammatory response and cartilage matrix degradation in human osteoarthritis chondrocytes. Journal of Orthopedic Research 32(4):573-80. (SCI)
  162. Chiu CY, Yen YP, Tsai KS, Yang RS, Liu SH* (2014) Low-dose benzo(a)pyrene and its epoxide metabolite inhibit myogenic differentiation in human skeletal muscle-derived progenitor cells. Toxicological Sciences 138(2):344-53. (SCI)
  163. Wu CT, Lu TY, Chan DC, Tsai KS, Yang RS, Liu SH* (2014) Effects of arsenic on osteoblast differentiation in vitro and on bone mineral density and microstructure in rats. Environmental Health Perspectives 122:559–565. (SCI)
  164. Chang HC, Tai YT, Cherng YG, Lin JW, Liu SH, Chen TL, Chen RM (2014) Resveratrol attenuates high-fat diet-induced disruption of the blood-brain barrier and protects brain neurons from apoptotic insults. Journal of Agricultural and Food Chemistry 62(15):3466-75. (SCI)
  165. Chen BL, Wang LT, Huang KH, Wang CC, Chiang CK, Liu SH* (2014) Quercetin attenuates renal ischemia/reperfusion injury via an activation of AMP-activated protein kinase-regulated autophagy pathway. Journal of Nutritional Biochemistry 25(11):1226-1234. (SCI)
  166. Guan SS, Chang JS, Cheng CC, Luo TY, Ho AS, Wang CC, Wu CT, Liu SH* (2014) Afatinib and its encapsulated polymeric micelles inhibits HER2-overexpressed colorectal tumor cell growth in vitro and in vivo. Oncotarget 5(13):4868-4880 (SCI)
  167. Lee WJ, Sheu WHH, Liu SH#, Yi YC, Chen WC, Lin SY, Liang KW, Shen CC, Yeh HY, Lin LY, Tsai YC, Tien HR, Lee MR, Yang TJ, Sheu ML (2014) Nε-carboxymethyllysine mediated ER stress promotes endothelial cell injury through Nox4/MKP-3 interaction. Free Radical Biology & Medicine 74:294-306. (SCI) (#: equal first-author)
  168. Liu SH, Lu TH, Su CC, Lay IS, Lin HY, Fang KM, Ho TJ, Chen KL, Su YC, Chiang WC, Chen YW (2014) Lotus Leaf (Nelumbo nucifera) and its Active Constituents Prevent Inflammatory Responses in Macrophages via JNK/NF-κB Signaling Pathway. American Journal of Chinese Medicine 42(4):869-89. (SCI)
  169. Lai DW,  Liu SH#,  Karlsson AI,  Lee WJ,  Wang KB,  Chen YC,  Shen CC,  Wu SM,  Liu CY,  Tien HR,  Peng YC,  Jan YJ,  Chao TH,  Lan KH,  Arbiser JL,   Sheu ML (2014) The novel Aryl hydrocarbon receptor inhibitor biseugenol inhibits gastric tumor growth and peritoneal dissemination. Oncotarget 5(17):7788-804. (SCI) (#: equal first-author)
  170. Chen BL, Sheu ML, Tsai KS, Lan KC, Guan SS, Wu CT, Chen LP, Hung KY, Huang JW, Chiang CK, Liu SH* (2015) CCAAT-enhancer-binding protein homologous protein deficiency attenuates oxidative stress and renal ischemia/reperfusion injury. Antioxidants & Redox Signaling 23, 1233–1245. (SCI)
  171. Chen YJ, Chan DC, Lan KC, Wang CC, Chen CM, Chao SC, Tsai KS, Yang RS, Liu SH* (2015) PPARγ is involved in the hyperglycemia-induced inflammatory responses and collagen degradation in human chondrocytes and diabetic mouse cartilages. Journal of Orthopedic Research 33(3):373-81. (SCI)
  172. Huang KT, Wu CT, Huang KH, Lin WC, Chen CM, Guan SS, Chiang CK, Liu SH* (2015) Titanium nanoparticles inhalation induces renal fibrosis in mice via an oxidative stress-up-regulated transforming growth factor-β pathway. Chemical Research in Toxicology 28(3):354-64. (SCI)
  173. Lee YE, Liu HC, Lin YL, Liu SH, Yang RS, Chen RM. (2015) Drynaria fortunei J. Sm. improves the bone mass of ovariectomized rats through osteocalcin-involved endochondral ossification. Journal of Ethnopharmacology 158 Pt A:94-101. (SCI)
  174. Tseng WT, Shih TW, Liu SH, Pan TM. (2015) Safety and mutagenicity evaluation of Vigiis 101 powder made from Lactobacillus paracasei subsp. paracasei NTU 101. Regulatory Toxicology and Pharmacology 71(2):148-57. (SCI)
  175. Liu SH, Lee WJ, Lai W, Wu SM, Liu CY, Tien HR, Chiu CS, Peng YC, Jan YJ, Chao TH, Pan HC, Sheu ML (2015) Honokiol confers immunogenicity by dictating calreticulin exposure, activating ER stress and inhibiting epithelial-to-mesenchymal transition. Molecular Oncology 9(4):834-49. (SCI)
  176. Chen CI, Kuan CF, Fang YA, Liu SH, Liu JC, Wu LL, Chun-Jen C, Yang HC, Hwang J, Miser JS, Wu SY (2015). Cancer Risk in HBV Patients with Statin and Metformin Use: A Population-based Cohort Study. Medicine 94(6):e462 (SCI)
  177. Chiu CY, Chan IL, Yang TH, Liu SH*, Chiang MT* (2015). Supplementation of Chitosan Alleviates High-Fat Diet-Enhanced Lipogenesis in Rats via Adenosine Monophosphate (AMP)-Activated Protein Kinase Activation and Inhibition of Lipogenesis-Associated Genes. Journal of Agricultural and Food Chemistry 63(11):2979-88. (SCI)
  178. Lan KC, Chiu CY, Kao CW, Huang KH, Wang CC, Huang KT, Tsai KS, Sheu ML, Liu SH* (2015). Advanced glycation end-products induce apoptosis in pancreatic islet endothelial cells via NF-κB-activated cyclooxygenase-2/prostaglandin E2 up-regulation. PLoS ONE 10(4):e0124418 (SCI)
  179. Huang CF, Yang CY, Chan DC, Wang CC, Huang KH, Wu CC, Tsai KS, Yang RS, Liu SH* (2015) Arsenic Exposure and Glucose Intolerance/Insulin Resistance in Estrogen-Deficient Female Mice. Environmental Health Perspectives 123(11):1138-44. (SCI)
  180. Lin WT, Chen RC, Lu WW, Liu SH*, Yang FY* (2015) Protective effects of low-intensity pulsed ultrasound on aluminum-induced cerebral damage in Alzheimer's disease rat model. Scientific Reports 5:9671 (SCI)
  181. Su CC1, Liu SH#, Lee KI, Huang KT, Lu TH, Fang KM, Wu CC, Yen CC, Lai CH, Su YC, Huang CF (2015) Cantharidin induces apoptosis through the calcium/pkc-regulated endoplasmic reticulum stress pathway in human bladder cancer cells. American Journal of Chinese Medicine 43(3):581-600 (SCI) (#: equal first-author)
  182. Guan SS, Sheu ML, Wu CT, Chiang CK, Liu SH* (2015) ATP synthase subunit-β down-regulation aggravates diabetic nephropathy. Scientific Reports 5:14561. (SCI)
  183. Liu SH, Yang RS, Yen YP, Chiu CY, Tsai KS, Lan KC (2015) Low-concentration arsenic trioxide inhibits skeletal myoblast cell proliferation via a reactive oxygen species-independent pathway. PLoS ONE 10(9):e0137907. (SCI)
  184. Ho MH, Yao CJ, Liao MH, Lin PI, Liu SH, Chen RM. (2015) Chitosan nanofiber scaffold improves bone healing via stimulating trabecular bone production due to upregulation of the Runx2/osteocalcin/alkaline phosphatase signaling pathway. International Journal of Nanomedicine 10:5941-54. (SCI)
  185. Guan SS, Cheng CC, Ho AS, Wang CC, Luo TY, Liao TZ, Chang J, Wu CT, Liu SH* (2015) Sulfonamide derivative targeting carbonic anhydrase IX as a nuclear imaging probe for colorectal cancer detection in vivo. Oncotarget 2015 Nov 3;6(34):36139-55. (SCI)
  186. Su WS, Tsai ML, Huang SL, Liu SH*, Yang FY* (2015) Controllable permeability of blood-brain barrier and reduced brain injury through low-intensity pulsed ultrasound stimulation. Oncotarget 6(39):42290-42299.
  187. Chen JH, Yen YC, Liu SH, Lee FP, Lin KC, Lai MT, Wu CC, Chen TM, Yuan SP, Chang CL, Wu SY (2015) Dementia Risk in Irradiated Patients With Head and Neck Cancer. Medicine 94(45):e1983.
  188. Ho IL, Kuo KL, Liu SH, Chang HC, Hsieh JT, Wu JT, Chiang CK, Lin WC, Tsai YC, Chou CT, Hsu CH, Pu YS, Shi CS, Huang KH. (2015) MLN4924 Synergistically Enhances Cisplatin-induced Cytotoxicity via JNK and Bcl-xL Pathways in Human Urothelial Carcinoma. Scientific Reports Nov 23;5:16948.
  189. Liu SH, Cai FY, Chiang MT. (2015) Long-term feeding of chitosan ameliorates glucose and lipid metabolism in a high-fructose-diet-impaired rat model of glucose tolerance. Marine Drugs 13: 7302–7313.
  190. Lin WC, Kuo KL, Shi CS, Wu JT, Hsieh JT, Chang HC, Liao SM, Chou CT, Chiang CK, Chiu WS, Chiu TY, Pu YS, Ho IL, Wang ZH, Chang SC, Liu SH,* Jeng YM, Huang KH*. (2015) MLN4924, a Novel NEDD8-activating enzyme inhibitor, exhibits antitumor activity and enhances cisplatin-induced cytotoxicity in human cervical carcinoma: in vitro and in vivo study. American Journal of Cancer Research Oct 15;5(11):3350-62.
  191. Lee WJ, Liu SH,# Chiang CK, Lin SY, Liang KW, Chen CH, Tien HR, Chen PH, Wu JP, Tsai YC, Lai DW, Chang YC, Sheu WHH, Sheu ML. (2016) Aryl Hydrocarbon receptor deficiency attenuates oxidative stress-related mesangial cell activation and macrophage infiltration and extracellular matrix accumulation in diabetic nephropathy. Antioxidants & Redox Signaling 24, 217-231. (SCI)
  192. Chen YJ, Chan DC, Chiang CK, Wang CC, Yang TH, Lan KC, Chao SC, Tsai KS, Yang RS, Liu SH* (2016) Advanced glycation end-products induced VEGF production and inflammatory responses in human synoviocytes via RAGE-NF-κB pathway activation. Journal of Orthopedic Research 34:791-800.
  193. Chiu CY, Yang RS, Sheu ML, Chan DC, Yang TH, Tsai KS, Chiang CK, Liu SH* (2016) Advanced glycation end products induce skeletal muscle atrophy and dysfunction in diabetic mice via an RAGE-mediated AMPK-downregulated Akt Pathway. Journal of Pathology Feb;238(3):470-82.
  194. Wu GJ, Wang W, Lin YL, Liu SH, Chen RM (2016). Oxidative stress-induced apoptotic insults to rat osteoblasts are attenuated by nitric oxide pretreatment via GATA-5-involved regulation of Bcl-X L gene expression and protein translocation. Archive Toxicology 90(4):905-16. (SCI)
  195. Hsieh JT, Kuo KL, Liu SH#, Shi CS, Chang HC, Lin WC, Chou CT, Hsu CH, Liao SM, Wang ZH, Li CC, Huang KH (2016) Epigallocatechin Gallate Attenuates Partial Bladder Outlet Obstruction-Induced Bladder Injury via Suppression of Endoplasmic Reticulum Stress-Related Apoptosis - in Vivo Study. Urology 2016 Jan 25; 91:242.e1-242.e9. (#: equal first author)
  196. Chen JH, Yen YC, Liu SH, Yuan SP, Wu LL, Lee FP, Lin KC, Lai MT, Wu CC, Chen TM, Chang CL, Chow JM, Ding YF, Lin MC, Wu SY. (2016). Outcomes of Induction Chemotherapy for Head and Neck Cancer Patients: A Combined Study of Two National Cohorts in Taiwan. Medicine (Baltimore). 2016 Feb;95(7):e2845.
  197. Liu SH, Wu CT, Huang KH, Wang CC, Guan SS, Chen LP, Chiang CK. (2016). C/EBP homologous protein (CHOP) deficiency ameliorates renal fibrosis in unilateral ureteral obstructive kidney disease. Oncotarget 2016 Mar 3. 7 (16): 21900-21912.
  198. Liu JC, Hsu YP, Kao PF, Hao WR, Liu SH, Lin CF, Sung LC, Wu SY. (2016). Influenza Vaccination Reduces Dementia Risk in Chronic Kidney Disease Patients: A Population-Based Cohort Study. Medicine (Baltimore). 2016 Mar;95(9):e2868.
    199. Liu SH, Yang CC, Chan DC, Wu CT, Chen LP, Huang JW, Hung KY, Chiang CK. (2016). Chemical chaperon 4-phenylbutyrate protects against the endoplasmic reticulum stress-mediated renal fibrosis in vivo and in vitro. Oncotarget 2016 Mar 3. 7 (16): 22116-22127.
  199. Lin CJ, Chang YA, Lin YL, Liu SH, Chang CK, Chen RM. (2016). Preclinical effects of honokiol on treating glioblastoma multiforme via G1 phase arrest and cell apoptosis. Phytomedicine 2016 May 15;23(5):517-27.
  200. Chen JH, Yen YC, Yang HC, Liu SH, Yuan SP, Wu LL, Lee FP, Lin KC, Lai MT, Wu CC, Chen TM, Chang CL, Chow JM, Ding YF, Wu SY. (2016) Curative-Intent Aggressive Treatment Improves Survival in Elderly Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma and High Comorbidity Index. Medicine (Baltimore). 2016 Apr;95(14):e3268.
  201. Guan SS, Sheu ML, Yang RS, Chan DC, Wu CT, Yang TH, Chiang CK, Liu SH*. (2016) The pathological role of advanced glycation end products-downregulated heat shock protein 60 in islet β-cell hypertrophy and dysfunction. Oncotarget 2016 Apr 5. 7(17): 23072-23087.
  202. Chen CM, Wu CT, Yang TH, Chang YA, Sheu ML, Liu SH*. (2016) Green tea catechin prevents hypoxia/reperfusion-evoked oxidative stress-regulated autophagy-activated apoptosis and cell death in microglial cells. Journal of Agricultural and Food Chemistry 2016 May 25. 64(20):4078-85.
  203. Liu SH, Lai YL, Chen BL, Yang FY. (2016) Ultrasound Enhances the Expression of Brain-Derived Neurotrophic Factor in Astrocyte Through Activation of TrkB-Akt and Calcium-CaMK Signaling Pathways. Cerebral Cortex 2016 Jun 1. [Epub ahead of print]
  204. Wu SY, Wu AT, Liu SH*. (2016) Microrna-17-5p regulated apoptosis-related protein expression and radiosensitivity in oral squamous cell carcinoma caused by betel nut chewing. Oncotarget 2016 Jun 6. 7(32):51482-51493.
  205. Lee KI, Su CC, Yang CY, Hung DZ, Lin CT, Lu TH, Liu SH*, Huang CF*. (2016) Etoposide induces pancreatic β-cells cytotoxicity via the JNK/ERK/GSK-3 signaling-mediated mitochondria-dependent apoptosis pathway. Toxicology In Vitro 2016 Jul 26. 36:142-152.
  206. Wu LL, Hsieh MC, Chow JM, Liu SH, Chang CL, Wu SY. (2016) Statins improve outcomes of nonsurgical curative treatments in hepatocellular carcinoma patients. Medicine (Baltimore). 2016 Sep;95(36):e4639.
  207. Chiang CK, Wang CC, Lu TF, Huang KH, Sheu ML, Liu SH*, Hung KY. (2016) Involvement of endoplasmic reticulum stress, autophagy, and apoptosis in advanced glycation end products-induced glomerular mesangial cell injury. Scientific Reports 2016 Sep 26;6:34167.
  208. Chen CC, Hsu YP, Liu JC, Kao PF, Sung LC, Lin CF, Hao WR, Liu SH, Wu SY. Statins dose-dependently exert significant chemopreventive effects against various cancers in chronic obstructive pulmonary disease patients: a population-based cohort study. Journal of Cancer 2016 Sep 13;7(13):1892-1900.

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